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KMID : 0880220110490010146
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Journal of Microbiology
2011 Volume.49 No. 1 p.146 ~ p.150
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Antifungal activity and mechanism of fengycin in the presence and absence of commercial surfactin against Rhizopus stolonifer
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Yang Tao
Xiao-mei Bie
Feng-xia Lv
Hai-zhen Zhao
Zhao-xin Lu
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Abstract
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The antifungal activity and mechanism of fengycin in the presence and absence of commercial surfactin against Rhizopus stolonifer were investigated. The MIC (minimal inhibitory concentration) of fengycin without commercial surfactin added was 0.4 mg/ml while the MIC of fengycin with commercial surfactin added was 2.0 mg/ml. Fengycin acted on cell membrane and cellular organs and inhibited DNA synthesis. The antifungal effect of fengycin was reduced after commercial surfactin was added. All these results suggest that the fungal cell membrane may be the primary target of fengycin action and commercial surfactin may reduce the antifungal activity of fengycin.
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KEYWORD
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Rhizopus stolonifer, lipopeptide, antifungal activity, mechanism, fengycin, commercial surfactin
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